FT-IR spectroscopy: a powerful tool in pharmacology

被引：18

作者：

Crupi, V

Majolino, D

Mondello, MR

Migliardo, P

Venuti, V

机构：

[1] Univ Messina, Dipartimento Fis, I-98166 Messina, Italy

[2] Univ Messina, Dipartimento Farmacobiol, I-98166 Messina, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 29卷 / 06期

关键词：

FT-IR absorption; medical physics; OH stretching region;

D O I：

10.1016/S0731-7085(02)00164-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In the present work we report a Fourier Transform Infrared (FT-IR) analysis performed on rat encephalon samples in the CH-OH vibrational stretching region (2400-3800) cm(-1), in order to reveal the presence of a very diffuse commercial benzodiazepine: VALIUM(R). The comparison between the spectral features of normal brain and the ones of samples with administrated substance has unambiguously showed that the CH stretching region seems not to suffer from any change for the pharmacological treatment, instead the OH band is strongly modified probably due to the presence of a new spectral contribution characteristic of diazepam molecule. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1149 / 1152

页数：4

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