The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids

被引：263

作者：

Rezk, BM

Haenen, GRMM

van der Vijgh, WJF

Bast, A

机构：

[1] Univ Maastricht, Fac Med, Dept Pharmacol & Toxicol, NL-6200 MD Maastricht, Netherlands

[2] Free Univ Amsterdam, Dept Med Oncol, Med Ctr, NL-1081 HV Amsterdam, Netherlands

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 295卷 / 01期

关键词：

phloretin; dihydrochalcone; flavonoid; peroxynitrite; lipid peroxidation;

D O I：

10.1016/S0006-291X(02)00618-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone. The potent activity of 2,6-dihydroxyacetophenone is due to stabilisation of its radical via tautomerisation. The antioxidant pharmacophore in the dihydrochalcone phloretin, i.e., the 2,6-dihydroxyacetophenone group, is different from the antioxidant pharmacophores previously reported in flavonoids. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：9 / 13

页数：5

共 14 条

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