Childhood obesity is associated with maternal smoking in pregnancy

被引:142
作者
Toschke, AM
Koletzko, B
Slikker, W
Hermann, M
von Kries, R
机构
[1] Univ Munich, Dept Paediat Epidemiol, Inst Social Paediat & Adolescent Med, D-81377 Munich, Germany
[2] Univ Munich, Dr Von Haunersch Childrens Hosp, Munich, Germany
[3] US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Jefferson, AR 72079 USA
关键词
Barker's hypothesis; body mass index; epidemiology; Germany; primary prevention;
D O I
10.1007/s00431-002-0983-z
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Overweight and obesity are major public health issues. Childhood obesity often persists throughout adulthood. Recently a higher prevalence of obesity in adults whose mothers smoked during pregnancy was reported. The aim of this study was to assess whether this association is also detectable in pre-school children in a different setting and to identify the critical period for intrauterine exposure to inhaled smoke products in pregnancy. We analysed questionnaire data on early feeding and lifestyle factors of 8,765 German children aged 5.00 to 6.99 years. Obesity was defined as a body mass index > 97th percentile. The prevalence estimates for obesity were: mother never smoked 2.8% (95% CI 2.4%-3.2%), smoked after pregnancy only 1.6% (95%CI 0.4%-4.1%), smoked throughout pregnancy 6.2% (95% Cl 4.5%-8.3%), smoked before pregnancy, but not throughout 4.5% (95%CI 3.6%5.7%). These associations could not be explained by confounding due to a number of constitutional, sociodemographic and lifestyle factors. The unadjusted/adjusted odds ratios were: smoked during pregnancy: 2.32 (95% CI 1.63%-3.30%)/1.92 (95% CI 1.29%-2.86%); smoked before, but not throughout pregnancy: 1.67 (95%CI 1.26%-2.22%)/1.74 (95%CI 1.29%-2.34%). Conclusion: the association of maternal smoking in pregnancy and obesity was also detectable in children at school entry. Since smoking after pregnancy was not associated with childhood obesity, intrauterine exposure rather than family lifestyle factors associated with smoking appears to be instrumental. There appears to be a role for early intrauterine exposure.
引用
收藏
页码:445 / 448
页数:4
相关论文
共 21 条
[1]  
ABRAHAM S, 1971, HSMHA HEALTH REP, V86, P273, DOI 10.2307/4594149
[2]   CIGARETTE-SMOKING IN PREGNANCY - ITS INFLUENCE ON BIRTH-WEIGHT AND PERINATAL MORTALITY [J].
BUTLER, NR ;
GOLDSTEIN, H ;
ROSS, EM .
BMJ-BRITISH MEDICAL JOURNAL, 1972, 2 (5806) :127-+
[3]   CHILDHOOD ANTECEDENTS OF ADULT OBESITY - DO CHUBBY INFANTS BECOME OBESE ADULTS [J].
CHARNEY, E ;
GOODMAN, HC ;
MCBRIDE, M ;
LYON, B ;
PRATT, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (01) :6-9
[4]   THE EFFECT OF CIGARETTE-SMOKING ON NEONATAL ANTHROPOMETRIC MEASUREMENTS [J].
CLIVER, SP ;
GOLDENBERG, RL ;
CUTTER, GR ;
HOFFMAN, HJ ;
DAVIS, RO ;
NELSON, KG .
OBSTETRICS AND GYNECOLOGY, 1995, 85 (04) :625-630
[5]   SMOKING IN PREGNANCY AND DEVELOPMENT INTO EARLY ADULTHOOD [J].
FOGELMAN, KR ;
MANOR, O .
BRITISH MEDICAL JOURNAL, 1988, 297 (6658) :1233-1236
[6]  
GOLDBLOOM R, 1994, CAN MED ASSOC J, V150, P871
[7]   MATERNAL SMOKING DURING PREGNANCY AND SMOKING BY ADOLESCENT DAUGHTERS [J].
KANDEL, DB ;
WU, P ;
DAVIES, M .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1994, 84 (09) :1407-1413
[8]   Prenatal nicotine effects on memory in rats: Pharmacological and behavioral challenges [J].
Levin, ED ;
Wilkerson, A ;
Jones, JP ;
Christopher, NC ;
Briggs, SJ .
DEVELOPMENTAL BRAIN RESEARCH, 1996, 97 (02) :207-215
[9]   Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort [J].
Montgomery, SM ;
Ekbom, A .
BRITISH MEDICAL JOURNAL, 2002, 324 (7328) :26-27
[10]   Prevalence of overweight among preschool children in the United States, 1971 through 1994 [J].
Ogden, CL ;
Troiano, RP ;
Briefel, RR ;
Kuczmarski, RJ ;
Flegal, M ;
Johnson, CL .
PEDIATRICS, 1997, 99 (04) :art. no.-e1