Combinatorial chemistry in the agrosciences

被引：47

作者：

Lindell, Stephen D. ^{[1
]}

Pattenden, Lisa C. ^{[1
]}

Shannon, Jonathan ^{[1
]}

机构：

[1] Bayer CropSci AG, Werk Hochst, D-65926 Frankfurt, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 12期

关键词：

Combinational chemistry; Library design and synthesis; Bioavailability guidelines; Briggs rule of three; Clarke-Delaney guide of two; Lead finding; Natural products; Privileged structures; Structure-based design; Virtual screening; Agrochemicals; Fungicides; Herbicides; Insecticides; SOLID-PHASE SYNTHESIS; PRIVILEGED STRUCTURES; PARALLEL SYNTHESIS; MOLECULAR-DOCKING; RATIONAL DESIGN; DRUG DISCOVERY; LIBRARY DESIGN; SURFACE-AREA; LEADS; PERFORMANCE;

D O I：

10.1016/j.bmc.2009.03.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Combinatorial chemistry and high throughput screening have had a profound effect upon the way in which agrochemical companies conduct their lead discovery research. The article reviews recent applications of combinatorial synthesis in the lead discovery process for new fungicides, herbicides and insecticides. The role and importance of bioavailability guidelines, natural products, privileged structures, virtual screening and X-ray crystallographic protein structures on the design of solid-and solution-phase compound libraries is discussed and illustrated. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4035 / 4046

页数：12

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