GOAT links dietary lipids with the endocrine control of energy balance

被引：307

作者：

Kirchner, Henriette ^{[1
,2
,3
,4
]}

Gutierrez, Jesus A. ^{[5
]}

Solenberg, Patricia J. ^{[5
]}

Pfluger, Paul T. ^{[1
,2
,3
]}

Czyzyk, Traci A. ^{[5
]}

Willency, Jill A. ^{[5
]}

Schuermann, Annette ^{[4
]}

Joost, Hans-Georg ^{[4
]}

Jandacek, Ronald J. ^{[1
,2
,3
]}

Hale, John E. ^{[5
]}

Heiman, Mark L. ^{[5
]}

Tschoep, Matthias H. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45221 USA

[2] Univ Cincinnati, Coll Med, Dept Med, Obes Res Ctr, Cincinnati, OH USA

[3] Univ Cincinnati, Coll Med, Genome Res Inst, Cincinnati, OH USA

[4] German Inst Human Nutr, Dept Pharmacol, Potsdam, Germany

[5] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 07期

基金：

美国国家卫生研究院;

关键词：

CHAIN FATTY-ACIDS; FOOD-INTAKE; GHRELIN; HORMONE; IDENTIFICATION; METABOLISM; SECRETION; PEPTIDE;

D O I：

10.1038/nm.1997

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

引用

页码：741 / 745

页数：5

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