Magnetic forces produced by rectangular permanent magnets in static microsystems

被引:66
作者
Gassner, Anne-Laure [1 ]
Abonnenc, Melanie [1 ]
Chen, Hong-Xu [2 ]
Morandini, Jacques [3 ]
Josserand, Jacques [1 ]
Rossier, Joel S. [4 ]
Busnel, Jean-Marc [1 ]
Girault, Hubert H. [1 ]
机构
[1] EPFL SB ISIC LEPA, Lab Electrochim Phys & Analyt, Stn 6, CH-1015 Lausanne, Switzerland
[2] Peking Univ, Coll Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
[3] Astek Rhone Alpes, F-38130 Echirolles, France
[4] DiagnoSwiss SA, CH-1870 Monthey, Switzerland
关键词
ON-COLUMN CAPTURE; MICROFLUIDIC SYSTEMS; BEAD; SEPARATION; PROTEIN; CHIP; PARTICLES; ELECTROMAGNETS; IMMUNOASSAY; MOLECULES;
D O I
10.1039/b901865d
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Finite element numerical simulations were carried out in 2D geometries to map the magnetic field and force distribution produced by rectangular permanent magnets as a function of their size and position with respect to a microchannel. A single magnet, two magnets placed in attraction and in repulsion have been considered. The goal of this work is to show where magnetic beads are preferentially captured in a microchannel. These simulations were qualitatively corroborated, in one geometrical case, by microscopic visualizations of magnetic bead plug formation in a capillary. The results show that the number of plugs is configuration dependent with: in attraction, one plug in the middle of the magnets; in repulsion, two plugs near the edges of the magnets; and with a single magnet, a plug close to the center of the magnet. The geometry of the magnets (h and l are the height and length of the magnets respectively) and their relative spacing s has a significant impact on the magnetic flux density. Its value inside a magnet increases with the h/l ratio. Consequently, bar magnets produce larger and more uniform values than flat magnets. The l/s ratio also influences the magnetic force value in the microchannel, both increasing concomitantly for all the configurations. In addition, a zero force zone in the middle appears in the attraction configuration as the l/s ratio increases, while with a single magnet, the number of maxima and minima goes from one to two, producing two focusing zones instead of only one.
引用
收藏
页码:2356 / 2363
页数:8
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