Novel activities of the Helicobacter pylori vacuolating cytotoxin:: from epithelial cells towards the immune system

被引：20

作者：

Fischer, W ^{[1
]}

Gebert, B ^{[1
]}

Haas, R ^{[1
]}

机构：

[1] LMU Munchen, Max Von Pettenkofer Inst Hyg & Med Microbiol, D-80336 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2004年 / 293卷 / 7-8期

关键词：

Helicobacter; cell vacuolation; IL-2; secretion; NFAT; calcineurin; immunophilins;

D O I：

10.1078/1438-4221-00300

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

H. pylori has developed a unique set of virulence factors, which allow its survival in a unique ecological niche, the human stomach. The vacuolating cytotoxin (VacA) and the cytotoxin-associated antigen (CagA) are major bacterial factors involved in modulating the host. VacA, so far mainly regarded as a cytotoxin for the gastric epithelial cell layer, apparently has profound effects in modulating the immune response. In this review we discuss some of the classical effects of VacA, such as cell vacuolation, and compare them with more recently identified mechanisms of VacA on immune cells.

引用

页码：539 / 547

页数：9

共 79 条

[1] Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA [J].

Amieva, MR ;

Vogelmann, R ;

Covacci, A ;

Tompkins, LS ;

Nelson, WJ ;

Falkow, S .

SCIENCE, 2003, 300 (5624) :1430-1434

[2] Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells [J].

Amieva, MR ;

Salama, NR ;

Tompkins, LS ;

Falkow, S .

CELLULAR MICROBIOLOGY, 2002, 4 (10) :677-690

[3] MOSAICISM IN VACUOLATING CYTOTOXIN ALLELES OF HELICOBACTER-PYLORI - ASSOCIATION OF SPECIFIC VACA TYPES WITH CYTOTOXIN PRODUCTION AND PEPTIC-ULCERATION [J].

ATHERTON, JC ;

CAO, P ;

PEEK, RM ;

TUMMURU, MKR ;

BLASER, MJ ;

COVER, TL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (30) :17771-17777

[4] The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms [J].

Boncristiano, M ;

Paccani, SR ;

Barone, S ;

Ulivieri, C ;

Patrussi, L ;

Ilver, D ;

Amedei, A ;

D'Elios, MM ;

Telford, JL ;

Baldari, CT .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) :1887-1897

[5] Phospholipase C-γ as a signal-transducing element [J].

Carpenter, G ;

Ji, QS .

EXPERIMENTAL CELL RESEARCH, 1999, 253 (01) :15-24

[6] IDENTIFICATION OF CALCINEURIN AS A KEY SIGNALING ENZYME IN LYMPHOCYTE-T ACTIVATION [J].

CLIPSTONE, NA ;

CRABTREE, GR .

NATURE, 1992, 357 (6380) :695-697

[7]

Cover TL, 2003, CANCER RES, V63, P951

[8]

COVER TL, 1992, J BIOL CHEM, V267, P10570

[9] Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly [J].

Cover, TL ;

Hanson, PI ;

Heuser, JE .

JOURNAL OF CELL BIOLOGY, 1997, 138 (04) :759-769

[10]

Cunningham KW, 1996, MOL CELL BIOL, V16, P2226

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