Incorporation of fluorescent probes into PAMAM dendrimers

被引：20

作者：

Domanski, DM ^{[1
]}

Klajnert, B ^{[1
]}

Bryszewska, M ^{[1
]}

机构：

[1] Univ Lodz, Dept Gen Biophys, PL-90237 Lodz, Poland

来源：

BIOELECTROCHEMISTRY | 2004年 / 63卷 / 1-2期

关键词：

PAMAM dendrimers; guest molecules; fluorescence; anisotropy; TMA-DPH; 12-AS;

D O I：

10.1016/j.bioelechem.2003.09.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interactions of two fluorescent probes 1-(trimethylammoniumphenyl)-6-phenyl-1,3,5 hexatriene p-toluenesulfonate (TMA-DPH) and 12-(9-anthroyloxy) stearic acid (12-AS) with polyamidoamine (PAMAM) dendrimers were studied. Changes in fluorescence intensity and steady-state fluorescence anisotropy of TMA-DPH and 12-AS were monitored. It was found that 12-AS molecules incorporated into dendrimer cavities whereas TMA-DPH molecules aggregated on the surface of polymer. Dendrimer size had not significant impact on its host properties. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：193 / 197

页数：5

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