PAQRs: A Counteracting Force to Ceramides?

被引：25

作者：

Holland, William L.

Scherer, Philipp E. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA

来源：

MOLECULAR PHARMACOLOGY | 2009年 / 75卷 / 04期

关键词：

INDUCED INSULIN-RESISTANCE; SPHINGOLIPID METABOLISM; ADIPONECTIN RECEPTORS; ADIPOSE-TISSUE; INHIBITION; MICE; DISRUPTION; ACTIVATION; DISEASE; KINASE;

D O I：

10.1124/mol.109.054817

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, sphingolipids have garnered increasing attention for their roles in modulating intracellular signaling events. Circulating factors associated with obesity promote excess accumulation of ceramide or glucosylceramide derivatives, which impair insulin action in peripheral tissues. In this issue, Villa et al. (p. 866) provide evidence that, in yeast, the progestin and adipoQ receptor superfamily of receptors mediate their effects via a novel ceramidase activity, generating sphingoid base as a second messenger.

引用

收藏

页码：740 / 743

页数：4

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