Imatinib in the treatment of solid tumours

被引：35

作者：

Duffaud, Florence ^{[1
]}

Le Cesne, Axel ^{[2
]}

机构：

[1] Ctr Hosp Univ, Assistance Publ Hop Marseille, Hop Enfants La Timone, F-13385 Marseille, France

[2] Inst Gustave Roussy, Villejuif, France

来源：

TARGETED ONCOLOGY | 2009年 / 4卷 / 01期

关键词：

Imatinib; Gatstrointestinal stromal tumors; Solid tumors; Dermatofibrosarcoma protuberans; Chordoma; Aggressive fibromatosis; GASTROINTESTINAL STROMAL TUMORS; ADENOID CYSTIC CARCINOMA; TYROSINE KINASE INHIBITOR; METASTATIC DERMATOFIBROSARCOMA PROTUBERANS; FAMILIAL ADENOMATOUS POLYPOSIS; SALIVARY-GLAND MALIGNANCIES; FIBROMATOSIS DESMOID TUMOR; GROWTH-FACTOR RECEPTORS; HIGH-DOSE IMATINIB; BONE-SARCOMA-GROUP;

D O I：

10.1007/s11523-008-0101-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The extraordinary success of imatinib in gastrointestinal stromal tumors (GIST) represents a model for molecularly targeted therapy for other solid tumors. Research is currently going to identify the molecular basis of mechanisms of action and drug resistance. In this article, we review recent advances in the clinical management of patients with GISTs treated with imatinib, but also of patients with dermatofibrosarcoma protuberans, chordoma, aggressive fibromatosis, and some other common solid tumors treated with this drug. We reviewed the knowledge of the molecular mechanisms that are basic to imatinib effects in these tumors.

引用

页码：45 / 56

页数：12

共 151 条

[1] THE MANAGEMENT OF DESMOID TUMORS [J].

ACKER, JC ;

BOSSEN, EH ;

HALPERIN, EC .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 26 (05) :851-858

[2]

Airoldi M, 2000, ANTICANCER RES, V20, P3781

[3]

Airoldi M, 2001, CANCER, V91, P541, DOI 10.1002/1097-0142(20010201)91:3<541::AID-CNCR1032>3.0.CO

[4]

2-Y

[5] Imatinib mesylate as treatment for adenoid cystic carcinoma of the salivary glands:: Report of two successfully treated cases [J].

Alcedo, JC ;

Fábrega, JM ;

Arosemena, JR ;

Urrutia, A .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2004, 26 (09) :829-831

[6] Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder [J].

Alman, BA ;

Pajerski, ME ;

DiazCano, S ;

Corboy, K ;

Wolfe, HJ .

DIAGNOSTIC MOLECULAR PATHOLOGY, 1997, 6 (02) :98-101

[7]

[Anonymous], CLIN PRACT GUID ONC

[8] Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation [J].

Antonescu, CR ;

Besmer, P ;

Guo, TH ;

Arkun, K ;

Hom, G ;

Koryotowski, B ;

Leversha, MA ;

Jeffrey, PD ;

Desantis, D ;

Singer, S ;

Brennan, MF ;

Maki, RG ;

DeMatteo, RP .

CLINICAL CANCER RESEARCH, 2005, 11 (11) :4182-4190

[9] CHORDOMA - NATURAL-HISTORY AND TREATMENT RESULTS IN 33 CASES [J].

AZZARELLI, A ;

QUAGLIUOLO, V ;

CERASOLI, S ;

ZUCALI, R ;

BIGNAMI, P ;

MAZZAFERRO, V ;

DOSSENA, G ;

GENNARI, L .

JOURNAL OF SURGICAL ONCOLOGY, 1988, 37 (03) :185-191

[10] Desmoid tumor: Prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy [J].

Ballo, MT ;

Zagars, GK ;

Pollack, A ;

Pisters, PWT ;

Pollock, RA .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (01) :158-167

← 1 2 3 4 5 6 7 8 9 10 →