Fat and carbohydrate metabolism during exercise in elderly and young subjects

被引:95
作者
Sial, S
Coggan, AR
Carroll, R
Goodwin, J
Klein, S
机构
[1] WASHINGTON UNIV, SCH MED, DEPT INTERNAL MED, ST LOUIS, MO 63110 USA
[2] UNIV TEXAS, MED BRANCH, DEPT INTERNAL MED, GALVESTON, TX 77555 USA
[3] UNIV TEXAS, MED BRANCH, DEPT ANESTHESIOL, GALVESTON, TX 77555 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1996年 / 271卷 / 06期
关键词
lipolysis; palmitate; glycerol; fatty acids; glycogen; stable isotopes;
D O I
10.1152/ajpendo.1996.271.6.E983
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We evaluated the effect of aging on fat and carbohydrate metabolism during moderate intensity exercise. Glycerol, free fatty acid (FFA), and glucose rate of appearance (R(a)) in plasma and substrate oxidation were determined during 60 min of cycle ergometer exercise in six elderly (73 +/- 2 yr) and six young adults (26 +/- 2 yr) matched by gender and lean body mass. The elderly group was studied during exercise performed at 56 +/- 3% of maximum oxygen uptake, whereas the young adults were studied during exercise performed at the same absolute and at a similar relative intensity as the elderly subjects. Mean fat oxidation during exercise was 25-35% lower in the elderly subjects than in the young adults exercising at either the same absolute or similar relative intensities (P < 0.05). Mean carbohydrate oxidation in the elderly group was 35% higher than the young adults exercising at the same absolute intensity (P < 0.001) but 40% lower than the young adults exercising at the same relative intensity (P < 0.001). Average FFA R(a) in the elderly subjects was 35% higher than in the young adults exercising at the same absolute intensity (P < 0.05) but 35% lower than the young adults exercising at a similar relative intensity (P < 0.05). We conclude that fat oxidation is decreased while carbohydrate oxidation is increased during moderate intensity exercise in elderly men and women. The shift in substrate oxidation was caused by age-related changes in skeletal muscle respiratory capacity because lipolytic rates and FFA availability were not rate limiting in the older subjects.
引用
收藏
页码:E983 / E989
页数:7
相关论文
共 35 条
[1]   ADRENERGIC REGULATION OF LIPOLYSIS INSITU AT REST AND DURING EXERCISE [J].
ARNER, P ;
KRIEGHOLM, E ;
ENGFELDT, P ;
BOLINDER, J .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (03) :893-898
[2]   EFFECT OF AGING ON LIPID COMPOSITION AND METABOLISM IN ADIPOSE TISSUES OF RAT [J].
BENJAMIN, W ;
GELLHORN, A ;
WAGNER, M ;
KUNDEL, H .
AMERICAN JOURNAL OF PHYSIOLOGY, 1961, 201 (03) :540-+
[3]  
BUSKIRK ER, 1987, FASEB J, V46, P1824
[4]   BASAL FAT OXIDATION DECREASES WITH AGING IN WOMEN [J].
CALLESESCANDON, J ;
ARCIERO, PJ ;
GARDNER, AW ;
BAUMAN, C ;
POEHLMAN, ET .
JOURNAL OF APPLIED PHYSIOLOGY, 1995, 78 (01) :266-271
[5]   EFFECT OF EXERCISE AND RECOVERY ON MUSCLE PROTEIN-SYNTHESIS IN HUMAN-SUBJECTS [J].
CARRARO, F ;
STUART, CA ;
HARTL, WH ;
ROSENBLATT, J ;
WOLFE, RR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (04) :E470-E476
[6]   EXERCISE TRAINING INDUCES GLYCOGEN SPARING DURING EXERCISE BY OLD RATS [J].
CARTEE, GD ;
FARRAR, RP .
JOURNAL OF APPLIED PHYSIOLOGY, 1988, 64 (01) :259-265
[7]   MUSCLE METABOLISM DURING EXERCISE IN YOUNG AND OLDER UNTRAINED AND ENDURANCE-TRAINED MEN [J].
COGGAN, AR ;
ABDULJALIL, AM ;
SWANSON, SC ;
EARLE, MS ;
FARRIS, JW ;
MENDENHALL, LA ;
ROBITAILLE, PM .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 75 (05) :2125-2133
[8]   HISTOCHEMICAL AND ENZYMATIC COMPARISON OF THE GASTROCNEMIUS-MUSCLE OF YOUNG AND ELDERLY MEN AND WOMEN [J].
COGGAN, AR ;
SPINA, RJ ;
KING, DS ;
ROGERS, MA ;
BROWN, M ;
NEMETH, PM ;
HOLLOSZY, JO .
JOURNALS OF GERONTOLOGY, 1992, 47 (03) :B71-B76
[9]  
DAVIES CTM, 1986, ACTA MED SCAND, P219
[10]  
DAX EM, 1981, J LIPID RES, V22, P934