Microfluidic Formation of Monodisperse, Cell-Sized, and Unilamellar Vesicles

被引：137

作者：

Ota, Sadao ^{[1
]}

Yoshizawa, Satoko ^{[3
]}

Takeuchi, Shoji ^{[1
,2
]}

机构：

[1] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo 1538505, Japan

[2] JST, PRESTO, Kawaguchi, Saitama 3320012, Japan

[3] Univ Tokyo, LIMMS CNRS IIS, UMI2820, Meguro Ku, Tokyo 1538505, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 35期

关键词：

artificial cells; lipid bilayers; microfluidics; synthetic biology; vesicles; PHOSPHOLIPID-VESICLES; DOUBLE-EMULSIONS; LIPOSOMES; MEMBRANE; BILAYER; DEVICE; PERMEABILITY; MODEL;

D O I：

10.1002/anie.200902182

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Gently down the stream: A microfluidic technique uses a continuous fluid stream to generate monodisperse unilamellar phospholipid vesicles from a single bilayer (see picture). Since the vesicles are robust and efficiently encapsulate high concentrations of various molecules, they are useful as delivery vehicles and as model cellular systems. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：6533 / 6537

页数：5

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