Genetic to genomic vaccination

被引：51

作者：

Johnston, SA ^{[1
]}

Barry, MA ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235

来源：

VACCINE | 1997年 / 15卷 / 08期

关键词：

expression library; genome; ELI;

D O I：

10.1016/S0264-410X(96)00276-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our development of genetic immunization (unfortunately named 'DNA'-immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector. This is particularly a problem with pathogens with large genomes such as bacteria and parasites. We have developed a potential solution to this problem termed 'expression library immunization.' It involves using expression libraries in genetic immunization vectors to basically strip down the genome into protective genes. It may offer a systematic, unbiased approach to discover vaccine candidates. (C) 1997 Elsevier Science Ltd.

引用

页码：808 / 809

页数：2