Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue

被引：8

作者：

Kojima, Naoshi

Sugino, Maiko

Mikami, Akiko

Nonaka, Ken

Fujinawa, Yumi

Muto, Isamu

Matsubara, Kenichi

Ohtsuka, Eiko

Komatsu, Yasuo

机构：

[1] Natl Inst Adv Ind Sci & Technol, Res Inst Genome Based Biofactory, Toyohira Ku, Sapporo, Hokkaido 0628517, Japan

[2] DNA Chip Res Inc, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[3] Hitachi Software Engn Co Ltd, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 19期

关键词：

amino-modified oligonucleotide; hydrophobic interaction; aromatic group;

D O I：

10.1016/j.bmcl.2006.07.027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the insertion of the aromatic residue could increase the reactivity of the amino group on oligo-nucleotides in comparison with conventional amino-modification. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5118 / 5121

页数：4

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