Synthesis and in vitro antitumour evaluation of benzothiazole-2-carbonitrile derivatives

被引：95

作者：

Bénéteau, V

Besson, T

Guillard, J

Léonce, S

Pfeiffer, B

机构：

[1] Univ La Rochelle, UPRES 2001, Lab Genie Prote & Cellulaire, F-17042 La Rochelle 1, France

[2] Inst Rech Servier, F-92150 Suresnes, France

[3] ADIR, F-92415 Courbevoie, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 34卷 / 12期

关键词：

imino-1,2,3-dithiazoles; antitumour activity; benzothiazoles; benzodioxines;

D O I：

10.1016/S0223-5234(99)00130-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel benzothiazole derivatives have been synthesised via the corresponding imino-1,2,3-dithiazoles. The cytotoxicity of some of these polyheterocyclic compounds was studied. Our results show that 2-cyano derivatives exhibit a medium in vitro antitumour activity. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

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收藏

页码：1053 / 1060

页数：8

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