HIV infection of non-dividing cells: a divisive problem

被引:62
作者
Fassati, Ariberto [1 ]
机构
[1] UCL, Div Infect & Immun, Wohl Virion Ctr, London W1T 4JF, England
[2] UCL, Div Infect & Immun, MRC UCL Ctr Med Mol Virol, London W1T 4JF, England
基金
英国惠康基金;
关键词
D O I
10.1186/1742-4690-3-74
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Understanding how lentiviruses can infect terminally differentiated, non-dividing cells has proven a very complex and controversial problem. It is, however, a problem worth investigating, for it is central to HIV-1 transmission and AIDS pathogenesis. Here I shall attempt to summarise what is our current understanding for HIV-1 infection of non-dividing cells. In some cases I shall also attempt to make sense of controversies in the field and advance one or two modest proposals.
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页数:15
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