Cholinergic control of heart rate by nitric oxide is site specific

被引：51

作者：

Herring, N ^{[1
]}

Danson, EJF ^{[1
]}

Paterson, DJ ^{[1
]}

机构：

[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷

关键词：

D O I：

10.1152/nips.01386.2002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Parasympathetic control of heart rate involves the exocytotic release of acetylcholine and muscarinic receptor regulation of pacemaking currents. Endogenous nitric oxide can potentially regulate all of these processes; however, recent work suggests that the main functional role of nitric oxide lies in the modulation of acetylcholine release.

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收藏

页码：202 / 206

页数：5

相关论文

共 20 条

[1] CONTROL OF CARDIAC-MUSCLE CELL-FUNCTION BY AN ENDOGENOUS NITRIC-OXIDE SIGNALING SYSTEM [J].

BALLIGAND, JL ;

KELLY, RA ;

MARSDEN, PA ;

SMITH, TW ;

MICHEL, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :347-351

[2] Muscarinic inhibitory and stimulatory regulation of the L-type Ca2+ current is not altered in cardiac ventricular myocytes from mice lacking endothelial nitric oxide synthase [J].

Belevych, AE ;

Harvey, RD .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 528 (02) :279-289

[3] Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice [J].

Choate, JK ;

Danson, EJF ;

Morris, JF ;

Paterson, DJ .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (06) :H2310-H2317

[4] Neuronal nitric oxide facilitates vagal chronotropic and dromotropic actions on the heart [J].

Conlon, K ;

Kidd, C .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1999, 75 (2-3) :136-146

[5]

Danson EJF, 2001, CIRCULATION, V104, P173

[6] Inotropic response to β-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts [J].

Gödecke, A ;

Heinicke, T ;

Kamkin, A ;

Kiseleva, I ;

Strasser, RH ;

Decking, UKM ;

Stumpe, T ;

Isenberg, G ;

Schrader, J .

JOURNAL OF PHYSIOLOGY-LONDON, 2001, 532 (01) :195-204

[7] Characteristics of nitric oxide-mediated cholinergic modulation of calcium current in rabbit sino-atrial node [J].

Han, X ;

Kobzik, L ;

Severson, D ;

Shimoni, Y .

JOURNAL OF PHYSIOLOGY-LONDON, 1998, 509 (03) :741-754

[8] AN OBLIGATORY ROLE FOR NITRIC-OXIDE IN AUTONOMIC CONTROL OF MAMMALIAN HEART-RATE [J].

HAN, X ;

SHIMONI, Y ;

GILES, WR .

JOURNAL OF PHYSIOLOGY-LONDON, 1994, 476 (02) :309-314

[9] Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase [J].

Han, XQ ;

Kubota, I ;

Feron, O ;

Opel, DJ ;

Arstall, MA ;

Zhao, YY ;

Huang, P ;

Fishman, MC ;

Michel, T ;

Kelly, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6510-6515

[10] Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atria [J].

Herring, N ;

Golding, S ;

Paterson, DJ .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2000, 32 (10) :1795-1804