Abnormal brain response of chronic schizophrenia patients despite normal performance during a visual vigilance task

被引:27
作者
Eyler, LT
Olsen, RK
Jeste, DV
Brown, GG
机构
[1] Vet Affairs San Diego Healthcare Syst, Mental Illness Res Educ & Clin Ctr, San Diego, CA 92161 USA
[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[3] NIMH, Clin Brain Disorders Branch, Unite Integrat Neuroimaging, Bethesda, MD 20892 USA
[4] Vet Affairs San Diego Healthcare Syst, Div geriatr Psychiat, La Jolla, CA 92161 USA
关键词
continuous performance test; functional magnetic resonance imaging; attention; prefrontal cortex;
D O I
10.1016/j.pscychresns.2004.01.003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Deficits of attention are common among individuals with schizophrenia (SZ) and are related both to genetic liability to the disorder and to functional outcome among patients. To explore the brain systems underlying these attentional abnormalities, we compared the response of nine patients with chronic SZ or schizoaffective disorder to that of 10 matched healthy individuals performing a simple visual vigilance task during functional magnetic resonance imaging. The two groups performed equivalently on the task. When the blood oxygen level dependent (BOLD) signal during identification of a target letter among similar-looking letters was compared to the response during fixation trials, both groups showed multiple clusters of significant brain response in widespread cortical regions. Compared with healthy participants, SZ patients showed a diminished response in the inferior frontal cortex and an abnormally enhanced response in right postcentral gyrus, right medial temporal lobe and left cerebellum. The results suggest that abnormalities of functional brain response to attentional tasks can be observed among patients with SZ even when behavioral performance is unimpaired, and provide further evidence that brain systems related to attention are likely to be involved in the pathophysiology of the disorder. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:245 / 257
页数:13
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