Higher viral load may explain the dominance of CRF02_AG in the molecular epidemiology of HIV in Ghana

被引：22

作者：

Fischetti, L ^{[1
]}

Opare-Sem, O

Candotti, D

Lee, H

Allain, JP

机构：

[1] Univ Cambridge, Dept Haematol, Div Transfus Med, Cambridge CB2 1TN, England

[2] Komfo Anokye Teaching Hosp, Dept Med, Kumasi, Ghana

[3] Cambridge Blood Ctr, Natl Blood Serv, Cambridge, England

来源：

AIDS | 2004年 / 18卷 / 08期

关键词：

D O I：

10.1097/00002030-200405210-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phylogenetic analysis of Ghanaian plasma samples from 84 asymptomatic candidate blood donors and 150 AIDS patients revealed a 63% prevalence of HIV-1 CRF02_AG. HIV-1 viral load in both populations was quantified using real-time reverse transcriptase-polymerase chain reaction. In asymptomatic candidate blood donors infected with CRF02_AG, the viral load was significantly higher than in donors infected with other HIV-1 molecular forms. A higher viral load of CRF02_AG is compatible with higher infectivity and prevalence.

引用

页码：1208 / 1210

页数：3

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