NP/MS since 1970: from the basement to the bench top

被引：25

作者：

Carter, Guy T. ^{[1
]}

机构：

[1] Carter Bernan Consulting, New City, NY 10956 USA

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 06期

关键词：

DESORPTION MASS-SPECTROMETRY; FAST-ATOM-BOMBARDMENT; FIELD DESORPTION; ELECTROSPRAY IONIZATION; STRUCTURE ELUCIDATION; NATURAL-PRODUCTS; HIGH-RESOLUTION; ANTIBIOTICS; SACCHAROMICINS; VANCOMYCIN;

D O I：

10.1039/c3np70085b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This Highlight explores the evolution of applications of mass spectrometric technologies in the context of natural products research since the 1970's. The central themes are the analysis of mixtures, dereplication (identification) and structure determination. The ascension of HPLC as the method of choice for the analysis of pharmaceuticals was a driving force for the development of interfaces for coupling of HPLC and MS. An example of sequential analysis of fragment ions or MS/MS or MSn methods to provide detailed structural information on muraymycins, a family of uridyl-peptide antibiotics, is presented.

引用

收藏

页码：711 / 717

页数：7

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