Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum

被引：82

作者：

Li, Yan-Qun ^{[1
]}

Wang, Shun-Fa

机构：

[1] S China Normal Univ, Coll Life Sci, Guangzhou 510631, Guangdong, Peoples R China

[2] Jiangxi Acad Sci, Nanchang 330029, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2006年 / 28卷 / 11期

关键词：

ganoderic acid; Ganoderma lucidum; hepatitis; hepatoprotection; virus;

D O I：

10.1007/s10529-006-9007-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ganoderic acid, from Ganoderma lucidum, at 8 mu g/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ganoderic acid at 10 mg and 30 mg/kg center dot d (by intravenous injection) 7 days. Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8).

引用

页码：837 / 841

页数：5

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