Vaccines for Pseudomonas aeruginosa: a long and winding road

被引：149

作者：

Priebe, Gregory P. ^{[1
,2
,3
,4
]}

Goldberg, Joanna B. ^{[5
]}

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Div Crit Care Med, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA

[3] Boston Childrens Hosp, Dept Med, Div Infect Dis, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Div Infect Dis, Boston, MA 02115 USA

[5] Emory Univ, Div Pulmonol Allergy Immunol Cyst Fibrosis & Slee, Dept Pediat, Sch Med,Rollins Res Ctr, Atlanta, GA 30322 USA

来源：

EXPERT REVIEW OF VACCINES | 2014年 / 13卷 / 04期

关键词：

alginate; Th17; vaccine; Pseudomonas aeruginosa; lipopolysaccharide; flagella; neutrophil; OUTER-MEMBRANE PROTEIN; CYSTIC-FIBROSIS PATIENTS; HUMAN MONOCLONAL-ANTIBODIES; HUMAN-IMMUNOGLOBULIN LOCI; COLONY-STIMULATING FACTOR; T-CELLS; MUCOID EXOPOLYSACCHARIDE; NEUTROPHIL RECRUITMENT; PSL EXOPOLYSACCHARIDE; PULMONARY INFECTION;

D O I：

10.1586/14760584.2014.890053

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Despite the recognition of Pseudomonas aeruginosa as an opportunistic pathogen, no vaccine against this bacteria has come to market. This review describes the current state-of-the-art in vaccinology for this bacterium. This includes a discussion of those at risk for infection, the types of vaccines and the approaches for empirical and targeted antigen selection under development, as well as a perspective on where the field should go. In addition, the challenges in developing a vaccine for those individuals at risk are discussed.

引用

页码：507 / 519

页数：13

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