Deformable boundary finding in medical images by integrating gradient and region information

Accurately segmenting and quantifying structures is a key issue in biomedical image analysis. The two conventional methods of image segmentation, region-based segmentation, and boundary finding, often suffer from a variety of limitations. Here we propose a method which endeavors to integrate the two approaches in an effort to form a unified approach that is robust to noise and poor initialization. Our approach uses Green's theorem to derive the boundary of a homogeneous region-classified area in the image and integrates this with a gray level gradient-based boundary finder. This combines the perceptual notions of edge/shape information with gray level homogeneity. A number of experiments were performed both on synthetic and real medical images of the brain and heart to evaluate the new approach, and it is shown that the integrated method typically performs better when compared to conventional gradient-based deformable boundary finding. Further, this method yields these improvements with little increase in computational overhead, an advantage derived from the application of the Green's theorem.