CCL2 (Monocyte Chemoattractant Protein-1) in cancer bone metastases

被引：190

作者：

Craig, Matt J.

Loberg, Robert D.

机构：

[1] Univ Michigan, Urol Ctr, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

CANCER AND METASTASIS REVIEWS | 2006年 / 25卷 / 04期

关键词：

cancer; chemokine; bone metastasis; chemokine receptor; tumorigenesis;

D O I：

10.1007/s10555-006-9027-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The paradigm of cancer development and metastasis is a comprehensive, complex series of events that ultimately reflects a coordinated interaction between the tumor cell and the microenvironment within which the tumor cell resides. Despite the realization that this relationship has changed the current paradigm of cancer research, the struggle continues to more completely understand the pathogenesis of the disease and the ability to appropriately identify and design novel targets for therapy. A particular area of research that has added a significant understanding to cancer metastasis is the role of chemokines and chemokine receptors. Here we review the current concepts of CCL2 (monoctye chemoattractant protein 1) and its role in tumor metastasis with particular interest to its role in the development of bone metastases.

引用

收藏

页码：611 / 619

页数：9

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