Serum Uric Acid and Hypertension in Adults: A Paradoxical Relationship in Type 1 Diabetes

被引：20

作者：

Bjornstad, Petter ^{[1
]}

Wadwa, R. Paul ^{[1
,2
]}

Sirota, Jeffrey C. ^{[3
]}

Snell-Bergeon, Janet K. ^{[1
,2
]}

McFann, Kimberly ^{[4
]}

Rewers, Marian ^{[1
,2
]}

Rivard, Christopher J. ^{[3
]}

Jalal, Diana ^{[3
]}

Chonchol, Michel B. ^{[3
]}

Johnson, Richard J. ^{[3
]}

Maahs, David M. ^{[1
,2
,3
]}

机构：

[1] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA

[2] Univ Colorado Denver, Barbara Davis Ctr Diabet, Aurora, CO USA

[3] Univ Colorado Denver, Dept Nephrol, Aurora, CO USA

[4] Univ Colorado, Sch Publ Hlth Biostat & Informat, Aurora, CO 80045 USA

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2014年 / 16卷 / 04期

关键词：

BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; RENAL-DISEASE; FILTRATION-RATE; CYSTATIN C; ALLOPURINOL; RISK; HYPERURICEMIA; ATHEROSCLEROSIS; PATHOGENESIS;

D O I：

10.1111/jch.12305

中图分类号：

R6 [外科学];

学科分类号：

100210 [外科学];

摘要：

Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults. Little is known about the relationship between serum uric acid and blood pressure in type 1 diabetes and whether it differs from the positive relationship found in nondiabetic adults. The authors assessed the cross-sectional and longitudinal relationships over 6 years between serum uric acid and blood pressure in adults with (35 +/- 9years [n=393]) and without (38 +/- 9years [n=685]) type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes study. In nondiabetic adults, serum uric acid was associated with systolic blood pressure in multivariable models adjusted for cardiovascular risk factors. In adults with type 1 diabetes, a negative association was observed between serum uric acid and systolic blood pressure after multivariable adjustments. A positive association was observed between serum uric acid and systolic blood pressure in nondiabetic adults. In contrast, an inverse relationship was demonstrated after multivariable adjustments in type 1 diabetes.

引用

页码：283 / 288

页数：6

共 40 条

[1]

Childhood uric acid predicts adult blood pressure - The Bogalusa Heart Study [J].

Alper, AB ;

Chen, W ;

Yau, L ;

Srinivasan, SR ;

Berenson, GS ;

Hamm, LL .

HYPERTENSION, 2005, 45 (01) :34-38

[2]

The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1α mutations is a feature of all patients with diabetes and is associated with glucosuria [J].

Bingham, C ;

Ellard, S ;

Nicholls, AJ ;

Pennock, CA ;

Allen, J ;

James, AJ ;

Satchell, SC ;

Salzmann, MB ;

Hattersley, AT .

DIABETES, 2001, 50 (09) :2047-2052

[3]

Bjornstad P, 2013, J DIABETES COMPLICAT

[4]

Early Diabetic Nephropathy A complication of reduced insulin sensitivity in type 1 diabetes [J].

Bjornstad, Petter ;

Snell-Bergeon, Janet K. ;

Rewers, Marian ;

Jalal, Diana ;

Chonchol, Michel B. ;

Johnson, Richard J. ;

Maahs, David M. .

DIABETES CARE, 2013, 36 (11) :3678-3683

[5]

Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [J].

Chobanian, AV ;

Bakris, GL ;

Black, HR ;

Cushman, WC ;

Green, LA ;

Izzo, JL ;

Jones, DW ;

Materson, BJ ;

Oparil, S ;

Wright, JT ;

Roccella, EJ .

HYPERTENSION, 2003, 42 (06) :1206-1252

[6]

US Trends in Prevalence, Awareness, Treatment, and Control of Hypertension, 1988-2008 [J].

Egan, Brent M. ;

Zhao, Yumin ;

Axon, R. Neal .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (20) :2043-2050

[7]

Eräranta A, 2008, J HYPERTENS, V26, P1661, DOI 10.1097/HJH.0b013e328303205d

[8]

URINE URIC-ACID EXCRETION IN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].

ERDBERG, A ;

BONER, G ;

VANDYK, DJ ;

CAREL, R .

NEPHRON, 1992, 60 (02) :134-137

[9]

Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension - A randomized trial [J].

Feig, Daniel I. ;

Soletsky, Beth ;

Johnson, Richard J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (08) :924-932

[10]

Uric Acid and the Origins of Hypertension [J].

Feig, Daniel I. ;

Madero, Magdalena ;

Jalal, Diana I. ;

Gabriela Sanchez-Lozada, L. ;

Johnson, Richard J. .

JOURNAL OF PEDIATRICS, 2013, 162 (05) :896-902

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