Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: A double-blind crossover placebo-controlled study

被引:55
作者
DeBenedittis, G
Lorenzetti, A
机构
[1] Pain Research and Treatment Unit, Institute of Neurosurgery, University of Milan, Milan
关键词
herpes zoster; postherpetic neuralgia; topical analgesics; aspirin/diethyl ether; indomethacin; diclofenac;
D O I
10.1016/0304-3959(95)00155-7
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The efficacy of topical aspirin/diethyl ether (ADE) mixture in the treatment of acute herpetic neuralgia and postherpetic neuralgia, suggested in a previous open-label study (De Benedittis et al. 1992), has been evaluated in a double-blind crossover placebo-controlled study as compared with two other NSAID (indomethacin and diclofenac) drug/ether mixtures. The study included 37 patients (15 with acute herpetic neuralgia (AHN) and 22 with postherpetic neuralgia (PHN)). Comparative treatment results showed that only aspirin (but not indomethacin and diclofenac) was significantly superior to placebo, as compared with baseline and duration of pain relief (P < 0.05 and P < 0.01, respectively), in both AHN and PHN groups. Good-to-excellent results were achieved by 87% of AHN patients and by 82% of PHN patients treated with the ADE mixture, with no significant differences between the two groups. On the whole, patients with trigeminal involvement, less severe pain and with dysaesthetic quality of pain yielded best results.
引用
收藏
页码:45 / 51
页数:7
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