Prothrombotic disturbances of hemostasis of patients with severe COVID-19: A prospective longitudinal observational study

被引：35

作者：

Hardy, Michael ^{[1
,2
]}

Michaux, Isabelle ^{[3
]}

Lessire, Sarah ^{[2
]}

Douxfils, Jonathan ^{[4
,5
]}

Dogne, Jean-Michel ^{[4
]}

Bareille, Marion ^{[1
]}

Horlait, Geoffrey ^{[3
]}

Bulpa, Pierre ^{[3
]}

Chapelle, Celine ^{[6
,7
]}

Laporte, Silvy ^{[6
,7
]}

Testa, Sophie ^{[8
]}

Jacqmin, Hugues ^{[1
]}

Lecompte, Thomas ^{[9
,10
]}

Dive, Alain ^{[3
]}

Mullier, Francois ^{[1
]}

机构：

[1] Catholic Univ Louvain, Namur Thrombosis & Hemostasis Ctr NTHC, CHU UCL Namur, Hematol Lab,Namur Res Inst Life Sci NARILIS, Yvoir, Belgium

[2] Catholic Univ Louvain, Namur Thrombosis & Hemostasis Ctr NTHC, CHU UCL Namur, Anesthesiol Dept,Namur Res Inst Life Sci NARILIS, Yvoir, Belgium

[3] Catholic Univ Louvain, CHU UCL Namur, Dept Intens Care, Yvoir, Belgium

[4] Univ Namur, Namur Thrombosis & Hemostasis Ctr NTHC, Namur Res Inst Life Sci NARILIS, Dept Pharm, Namur, Belgium

[5] Qualiblood Sa, Namur, Belgium

[6] Hop Nord St Etienne, CHU St Etienne, Unit Rech Clin Innovat Pharmacol, F-42055 St Etienne, France

[7] Univ Lyon, Univ Jean Monnet, SAINBIOSE U1059, INSERM,FCRIN INNOVTE Network, F-42023 St Etienne, France

[8] Cremona Hosp, Haemostasis & Thrombosis Ctr, Cremona, Italy

[9] Univ Geneva, Hop Univ Geneve, Serv Angiol & Hemostase, Dept Med, Geneva, Switzerland

[10] Univ Geneva, Fac Med, Geneva Platelet Grp GpG, Geneva, Switzerland

来源：

THROMBOSIS RESEARCH | 2021年 / 197卷

关键词：

COVID19; Fibrinolysis; Intensive care; Thrombin generation; PAI-1; D-dimers; Fibrinogen; Factor VIII;

D O I：

10.1016/j.thromres.2020.10.025

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页码：20 / 23

页数：4

共 10 条

[1]

A new assay for global fibrinolysis capacity (GFC): Investigating a critical system regulating hemostasis and thrombosis and other extravascular functions [J].

Amiral, Jean ;

Laroche, Maxime ;

Seghatchian, Jerard .

TRANSFUSION AND APHERESIS SCIENCE, 2018, 57 (01) :118-126

[2]

Thrombin generation measurement using the ST Genesia Thrombin Generation System in a cohort of healthy adults: Normal values and variability [J].

Calzavarini, Sara ;

Brodard, Justine ;

Quarroz, Claudia ;

Maire, Livia ;

Nuetzi, Raphael ;

Jankovic, Jovana ;

Rotondo, Laura C. ;

Giabbani, Evelyne ;

Fiedler, Georg Martin ;

Nagler, Michael ;

Angelillo-Scherrer, Anne .

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2019, 3 (04) :758-768

[3]

Features of severe COVID-19: A systematic review and meta-analysis [J].

Del Sole, Francesco ;

Farcomeni, Alessio ;

Loffredo, Lorenzo ;

Carnevale, Roberto ;

Menichelli, Danilo ;

Vicario, Tommasa ;

Pignatelli, Pasquale ;

Pastori, Daniele .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2020, 50 (10)

[4]

Management of the thrombotic risk associated with COVID-19: guidance for the hemostasis laboratory [J].

Hardy, M. ;

Lecompte, T. ;

Douxfils, J. ;

Lessire, S. ;

Dogne, J. M. ;

Chatelain, B. ;

Testa, S. ;

Gouin-Thibault, I. ;

Gruel, Y. ;

Medcalf, R. L. ;

ten Cate, H. ;

Lippi, G. ;

Mullier, F. .

THROMBOSIS JOURNAL, 2020, 18 (01)

[5]

Studies on hemostasis in COVID-19 deserve careful reporting of the laboratory methods, their significance, and their limitations [J].

Hardy, Michael ;

Douxfils, Jonathan ;

Bareille, Marion ;

Lessire, Sarah ;

Gouin-Thibault, Isabelle ;

Fontana, Pierre ;

Lecompte, Thomas ;

Mullier, Francois .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 18 (11) :3121-3124

[6]

Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis [J].

Nougier, Christophe ;

Benoit, Remi ;

Simon, Marie ;

Desmurs-Clavel, Helene ;

Marcotte, Guillaume ;

Argaud, Laurent ;

David, Jean Stephane ;

Bonnet, Aurelie ;

Negrier, Claude ;

Dargaud, Yesim .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 18 (09) :2215-2219

[7]

Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring [J].

Susen, Sophie ;

Tacquard, Charles Ambroise ;

Godon, Alexandre ;

Mansour, Alexandre ;

Garrigue, Delphine ;

Nguyen, Philippe ;

Godier, Anne ;

Testa, Sophie ;

Levy, Jerrold H. ;

Albaladejo, Pierre ;

Gruel, Yves .

CRITICAL CARE, 2020, 24 (01)

[8]

COVID-19 versus HIT hypercoagulability [J].

Warkentin, Theodore E. ;

Kaatz, Scott .

THROMBOSIS RESEARCH, 2020, 196 :38-51

[9]

Fibrinolysis Resistance: A Potential Mechanism Underlying COVID-19 Coagulopathy [J].

Weiss, Emmanuel ;

Roux, Olivier ;

Moyer, Jean-Denis ;

Paugam-Burtz, Catherine ;

Boudaoud, Larbi ;

Ajzenberg, Nadine ;

Faille, Dorothee ;

de Raucourt, Emmanuelle .

THROMBOSIS AND HAEMOSTASIS, 2020, 120 (09) :1343-1345

[10]

White D., 2020, INT J LAB HEMATOL, P1

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