Structure and function of cellular deoxyribonucleoside kinases

被引：255

作者：

Eriksson, S

Munch-Petersen, B

Johansson, K

Eklund, H

机构：

[1] Swedish Univ Agr Sci, Dept Mol Biol, Biomed Ctr, S-75124 Uppsala, Sweden

[2] Roskilde Univ, Dept Chem & Life Sci, DK-4000 Roskilde, Denmark

[3] Swedish Univ Agr Sci, Dept Vet Med Chem, Biomed Ctr, S-75124 Uppsala, Sweden

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 08期

关键词：

deoxyribonuncleoside kinases; substrate specificity; phosphoryl transfer; nucleoside analogs; feedback inhibition; biochemical properties;

D O I：

10.1007/s00018-002-8511-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides, a crucial reaction in biosynthesis of DNA precursors through the salvage pathway. Their medical interest stems from their activation of a number of anticancer and antiviral drugs such as 2-chloro-2'-deoxyadenosine, azidothymidine and acyclovir. Here we review what is presently known about each of the mammalian kinases as well as some other members of the deoxyribonucleoside kinase family. A description of the biochemical properties of the enzymes is followed by an overview of the structural studies made on this family of enzymes, including the catalytic mechanism as well as the mechanism for feedback inhibition. A presentation of homology models of other proteins in the family is made and, finally, the determinants of substrate and substrate analog specificities are described.

引用

页码：1327 / 1346

页数：20

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