Bioenergetics of aging and calorie restriction

被引：48

作者：

Hunt, Nicole D.

Hyun, Dong-Hoon

Allard, Joanne S.

Minor, Robin K.

Mattson, Mark P.

Ingram, Donald K.

de Cabo, Rafael

机构：

[1] NIA, Lab Expt Gerontol, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA

[2] NIA, Lab Neurosci, NIH, Baltimore, MD 21224 USA

来源：

AGEING RESEARCH REVIEWS | 2006年 / 5卷 / 02期

关键词：

aging; calorie restriction; bioenergetics; oxidative damage;

D O I：

10.1016/j.arr.2006.03.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused on determining why there is an age-dependent decrease in cellular bioenergetics. The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined. Published by Elsevier Ireland Ltd.

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页码：125 / 143

页数：19

相关论文

共 155 条

[1] Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Sinclair, DA .

NATURE, 2003, 423 (6936) :181-185

[2] Age-dependent modifications in the metabolism of mevalonate pathway lipids in rat brain [J].

Andersson, M ;

Aberg, F ;

Teclebrhan, H ;

Edlund, C ;

Appelkvist, EL .

MECHANISMS OF AGEING AND DEVELOPMENT, 1995, 85 (01) :1-14

[3] Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake [J].

Anson, RM ;

Guo, ZH ;

de Cabo, R ;

Iyun, T ;

Rios, M ;

Hagepanos, A ;

Ingram, DK ;

Lane, MA ;

Mattson, MP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :6216-6220

[4] EFFECT OF DIETARY RESTRICTION AND OR EXERCISE ON 23-H METABOLIC-RATE AND BODY-COMPOSITION IN FEMALE RATS [J].

BALLOR, DL .

JOURNAL OF APPLIED PHYSIOLOGY, 1991, 71 (03) :801-806

[5] Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart [J].

Barazzoni, R ;

Short, KR ;

Nair, KS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (05) :3343-3347

[6] Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals [J].

Barja, G ;

Herrero, A .

FASEB JOURNAL, 2000, 14 (02) :312-318

[7] Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging [J].

Barrientos, A ;

Casademont, J ;

Cardellach, F ;

Estivill, X ;

Urbano-Marquez, A ;

Nunes, V .

MOLECULAR BRAIN RESEARCH, 1997, 52 (02) :284-289

[8] Late-onset mitochondrial DNA depletion:: DNA copy number, multiple deletions, and compensation [J].

Barthélémy, C ;

de Baulny, HO ;

Diaz, J ;

Cheval, MA ;

Frachon, P ;

Romero, N ;

Goutieres, F ;

Fardeau, M ;

Lombès, A .

ANNALS OF NEUROLOGY, 2001, 49 (05) :607-617

[9] COENZYME-Q CONTENT IN SYNAPTIC AND NONSYNAPTIC MITOCHONDRIA FROM DIFFERENT BRAIN-REGIONS IN THE AGING RAT [J].

BATTINO, M ;

GORINI, A ;

VILLA, RF ;

GENOVA, ML ;

BOVINA, C ;

SASSI, S ;

LITTARRU, GP ;

LENAZ, G .

MECHANISMS OF AGEING AND DEVELOPMENT, 1995, 78 (03) :173-187

[10] Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila [J].

Bayne, ACV ;

Mockett, RJ ;

Orr, WC ;

Sohal, RS .

BIOCHEMICAL JOURNAL, 2005, 391 (02) :277-284

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