Novel polyelectrolyte carboxymethyl konjac glucomannan-chitosan nanoparticles for drug delivery

被引：58

作者：

Du, J

Sun, R

Zhang, S

Govender, T

Zhang, LF

Xiong, CD ^{[1
]}

Peng, YX

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[2] Univ KwaZulu Natal, Sch Pharmaceut Sci, ZA-4000 Durban, South Africa

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2004年 / 25卷 / 09期

关键词：

chitosan; drug delivery systems; matrix; nanoparticles; polyelectrolytes;

D O I：

10.1002/marc.200300314

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理]; 080501 [材料物理与化学]; 081704 [应用化学];

摘要：

Carboxymethyl Konjac Glucomannan-Chitosan (CKGM-CS) nanoparticles, which are well dispersed and stable in aqueous solution, were spontaneously prepared under very mild conditions by polyelectrolyte complexation. Investigations of the physicochemical properties of these nanoparticles were undertaken. This study showed that the nanoparticulate system driven by complex formation has potential as an advanced drug-delivery system for water-soluble drugs.

引用

页码：954 / 958

页数：5

共 14 条

[1]

Utilization of soy protein isolate and konjac blends in a low-fat bologna (model system) [J].