Development of chiral pincer palladium complexes bearing a pyrroloimidazolone unit. Catalytic use for asymmetric Michael addition

被引:83
作者
Takenaka, K [1 ]
Uozumi, Y [1 ]
机构
[1] IMS, Okazaki, Aichi 4448787, Japan
关键词
D O I
10.1021/ol0494515
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Novel pincer palladium complexes having chiral hexahydro-1H-pyrrolo[1,2-c]imidazolone groups were designed and prepared. Catalytic asymmetric Michael addition of isopropyl 2-cyanopropionate to ethyl vinyl ketone was catalyzed by the chiral pincer palladium complex to give isopropyl 2-cyano-2-methyl-5-oxoheptanoate with high enantioselectivity (up to 83% ee).
引用
收藏
页码:1833 / 1835
页数:3
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