Structure-activity relationship study of asiatic acid derivatives against beta amyloid (Aβ)-induced neurotoxicity

被引：65

作者：

Jew, SS

Yoo, CH

Lim, DY

Kim, H

Mook-Jung, I

Jung, MW

Choi, H

Jung, YH

Kim, H

Park, HG

机构：

[1] Seoul Natl Univ, Coll Pharm, Kwanak Gu, Seoul 151742, South Korea

[2] Ajou Univ, Sch Med, Brain Dis Res Ctr, Suwon 441749, South Korea

[3] Ajou Univ, Sch Med, Inst Med Sci, Suwon 441749, South Korea

[4] Dong Kook Pharmaceut Co Ltd, Cent Res Inst, Choong Cheong Book Do, South Korea

[5] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea

[6] Sookmyung Woman Univ, Coll Pharm, Seoul, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(99)00658-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against AP-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：119 / 121

页数：3

共 15 条

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FURCHT SJ, 1994, NEUROPATH EXP NEUROL, V52, P640

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