The third function of the thymus

被引：189

作者：

Seddon, B

Mason, D

机构：

[1] Natl Inst Med Res, Div Mol Immunol, London NW7 1AA, England

[2] Univ Oxford, Sir William Dunn Sch Pathol, MRC, Cellular Immunol Unit, Oxford OX1 3RE, England

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 02期

关键词：

D O I：

10.1016/S0167-5699(99)01559-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonresponsiveness of mammalian T cells to self-antigens is not totally accounted for in terms of clonal deletion, T-cell anergy and T-cell ignorance: studies have shown that the T-cell repertoire of healthy individuals contains cells with the potential to cause autoimmune disease. This article describes a T-cell-mediated mechanism that prevents the realization of this potential and indicates how its failure can lead to the development of autoimmunity.

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页码：95 / 99

页数：5

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