Nuclear factor kappa B - molecular biomedicine: the next generation

被引：83

作者：

Celec, P ^{[1
]}

机构：

[1] Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia

[2] Comenius Univ, Fac Nat Sci, Dept Biol Mol, Bratislava, Slovakia

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2004年 / 58卷 / 6-7期

关键词：

nuclear factor kappa B; apoptosis; cell cycle regulation; immunosuppressive therapy; inflammation;

D O I：

10.1016/j.biopha.2003.12.015

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Nuclear factor kappa B (NFkappaB) as a transcription factor plays an important integrating role in the intracellular regulation of immune response, inflammation and cell cycle regulation. Nouvelle insights into the structure and regulation of activation of NFkappaB have brought a detailed picture of the function of this transcription factor. In this review the findings of interactions of NFkappaB with its inhibitors, tumour necrosis factor alpha and glucocorticoids are presented. The results from the latest in vivo studies show the capability of specific NFkappaB inhibitors in the clinical use. This article summarizes the most important facts regarding NFkappaB participation in the pathogenesis of diseases and its potential as a target of pharmacological agents. (C) 2004 Elsevier SAS. All tights reserved.

引用

收藏

页码：365 / 371

页数：7

相关论文

共 82 条

[1]

A role for NF-κB-dependent gene transactivation in sunburn [J].

Abeyama, K ;

Eng, W ;

Jester, JV ;

Vink, AA ;

Edelbaum, D ;

Cockerell, CJ ;

Bergstresser, PR ;

Takashima, A .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (12) :1751-1759

[2]

Potential roles for tumor necrosis factor and nuclear factor-κB in seizure activity [J].

Albensi, BC .

JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 66 (02) :151-154

[3]

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[4]

Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBα/NF-κB pathway in limb-girdle muscular dystrophy type 2A [J].

Baghdiguian, S ;

Martin, M ;

Richard, I ;

Pons, F ;

Astier, C ;

Bourg, N ;

Hay, RT ;

Chemaly, R ;

Halaby, G ;

Loiselet, J ;

Anderson, LVB ;

de Munain, AL ;

Fardeau, M ;

Mangeat, P ;

Beckmann, JS ;

Lefranc, G .

NATURE MEDICINE, 1999, 5 (05) :503-511

[5]

An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].

Beg, AA ;

Baltimore, D .

SCIENCE, 1996, 274 (5288) :782-784

[6]

Bhakar AL, 2002, J NEUROSCI, V22, P8466

[7]

Diabetes-associated sustained activation of the transcription factor nuclear factor-κB [J].

Bierhaus, A ;

Schiekofer, S ;

Schwaninger, M ;

Andrassy, M ;

Humpert, PM ;

Chen, J ;

Hong, M ;

Luther, T ;

Henle, T ;

Klöting, I ;

Morcos, M ;

Hofmann, M ;

Tritschler, H ;

Weigle, B ;

Kasper, M ;

Smith, M ;

Perry, G ;

Schmidt, AM ;

Stern, DM ;

Häring, HU ;

Schleicher, E ;

Nawroth, PP .

DIABETES, 2001, 50 (12) :2792-2808

[8]

The nuclear factor kappa B (NF-κB):: A potential therapeutic target for estrogen receptor negative breast cancers [J].

Biswas, DK ;

Dai, SC ;

Cruz, A ;

Weiser, B ;

Graner, E ;

Pardee, AB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10386-10391

[9]

Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-κB to protect endothelial cells from tumor necrosis factor-α-mediated apoptosis [J].

Brouard, S ;

Berberat, PO ;

Tobiasch, E ;

Seldon, MP ;

Bach, FH ;

Soares, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (20) :17950-17961

[10]

Vitamin E inhibits hepatic NF-κB activation in rats administered the hepatic tumor promoter, phenobarbital [J].

Calfee-Mason, KG ;

Spear, BT ;

Glauert, HP .

JOURNAL OF NUTRITION, 2002, 132 (10) :3178-3185

← 1 2 3 4 5 6 7 8 9 →