Seprafilm superior to Gore-Tex in the prevention of peridural fibrosis

被引:33
作者
Topsakal, C
Akpolat, N
Erol, FS
Ozveren, MF
Akdemir, I
Kaplan, M
Tiftikci, M
Kilic, N
机构
[1] Firat Univ, Sch Med, Dept Neurosurg, Elazig, Turkey
[2] Firat Univ, Sch Med, Dept Pathol, Elazig, Turkey
[3] Firat Univ, Sch Med, Dept Biochem, Elazig, Turkey
关键词
adhesion; peridural fibrosis; scar; Gore-Tex; seprafilm;
D O I
10.3171/jns.2004.101.2.0295
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Object. This is an investigation into the effects of two barrier membranes in the prevention of peridural fibrosis in an animal model. Methods. Seprafilm or Gore-Tex was applied to a laminectomy defect overlying the dura mater in rats separated into treatment groups. A third group of rats underwent laminectomy only and served as controls. Two months postoperatively a histological study was performed to compare the amount of scar tissue in each group. The gross dissection demonstrated that both membranes created a controlled dissection plane, facilitated access to the epidural space, and provided a reduction in the amount of tissue adhering to the dura mater. Statistically, Seprafilm was superior to Gore-Tex in preventing peridural fibrosis (p < 0.05). Conclusions. Seprafilm can prevent peridural fibrosis better than Gore-Tex and can be used in humans in spinal surgery.
引用
收藏
页码:295 / 302
页数:8
相关论文
共 61 条
[1]   The use of Gore-Tex membrane for adhesion prevention in tethered spinal cord surgery: Technical case reports [J].
Aliredjo, RP ;
de Vries, J ;
Menovsky, T ;
Grotenhuis, JA ;
Merx, J .
NEUROSURGERY, 1999, 44 (03) :674-677
[2]   Evaluation of resorbable barriers for preventing surgical adhesions [J].
Arnold, PB ;
Green, CW ;
Foresman, PA ;
Rodeheaver, GT .
FERTILITY AND STERILITY, 2000, 73 (01) :157-161
[3]   Seprafilm reduces adhesions to polypropylene mesh [J].
Baptista, ML ;
Bonsack, ME ;
Delaney, NP .
SURGERY, 2000, 128 (01) :86-92
[4]   PROPHYLAXIS OF LAMINECTOMY MEMBRANE - EXPERIMENTAL-STUDY IN DOGS [J].
BARBERA, J ;
GONZALEZ, J ;
ESQUERDO, J ;
BROSETA, J ;
BARCIASALORIO, JL .
JOURNAL OF NEUROSURGERY, 1978, 49 (03) :419-424
[5]   REPAIR OF LARGE ABDOMINAL-WALL DEFECTS WITH EXPANDED POLYTETRAFLUOROETHYLENE (PTFE) [J].
BAUER, JJ ;
SALKY, BA ;
GELERNT, IM ;
KREEL, I .
ANNALS OF SURGERY, 1987, 206 (06) :765-769
[6]  
Baykal A, 2000, CAN J SURG, V43, P43
[7]  
Beck DE, 1997, EUR J SURG, V163, P49
[8]   2 IMPROVED AND SIMPLIFIED METHODS FOR SPECTROPHOTOMETRIC DETERMINATION OF HYDROXYPROLINE [J].
BERGMAN, I ;
LOXLEY, R .
ANALYTICAL CHEMISTRY, 1963, 35 (12) :1961-&
[9]  
BLAUER KL, 1988, FERTIL STERIL, V49, P144
[10]  
BOOT DA, 1987, CLIN ORTHOP RELAT R, V215, P296