The continuous spread of West Nile virus (WNV): seroprevalence in asymptomatic horses

被引：22

作者：

Alonso-Padilla, J. ^{[1
]}

Loza-Rubio, E. ^{[2
]}

Escribano-Romero, E. ^{[1
]}

Cordoba, L. ^{[1
]}

Cuevas, S. ^{[2
]}

Mejia, F. ^{[2
]}

Calderon, R. ^{[2
]}

Milian, F. ^{[2
]}

da Rosa, A. Travassos ^{[3
,4
]}

Weaver, S. C. ^{[3
,4
]}

Estrada-Franco, J. G. ^{[3
,4
]}

Saiz, J. C. ^{[1
]}

机构：

[1] Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Dept Biotecnol, Madrid 28040, Spain

[2] Inst Nacl Invest Agr Forestales & Pecuarias CENID, Colonia Palo Alto, Mexico

[3] Univ Texas Med Branch, Dept Pathol, Galveston, TX USA

[4] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX USA

来源：

EPIDEMIOLOGY AND INFECTION | 2009年 / 137卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Emerging viruses; serology; viral expansion; viruses; zoonoses; TRANSMISSION DYNAMICS; SEROLOGIC EVIDENCE; MEXICO; ANTIBODIES; EPIDEMIOLOGY; INFECTION; DISEASE; BIRDS; STATE;

D O I：

10.1017/S0950268809002325

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

West Nile virus (WNV) was probably introduced in southern and northern Mexico from the USA in two independent events. Since then, WNV activity has been reported in several Mexican states bordering the USA and the Gulf of Mexico, but disease manifestations seen there in humans and equids are quite different to those observed in the USA. We have analysed WNV seroprevalence in asymptomatic, unvaccinated equids from two Mexican states where no data had been previously recorded. WNV IgG antibodies were detected in 31.6% (91/288) of equine sera from Chiapas and Puebla states (53.3% and 8.0%, respectively). Analysis by plaque reduction neutralization test (PRNT) showed good specificity (99.4%) and sensitivity (84.9%) with the ELISA results. Further analyses to detect antibodies against three different flaviviruses (WNV, St Louis encephalitis virus, Ilheus virus) by haemagglutination inhibition (HI) tests on a subset of 138 samples showed that 53% of the 83 HI-positive samples showed specific reaction to WNV. These data suggest continuous expansion of WNV through Mexico.

引用

页码：1163 / 1168

页数：6

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