Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues

被引：24

作者：

De Jonghe, S

Van Overmeire, I

Gunst, J

De Bruyn, A

Hendrix, C

Van Calenbergh, S

Busson, R

De Keukeleire, D

Philippé, J

Herdewijn, P

机构：

[1] Univ Ghent, Fac Pharmaceut Sci, Med Chem Lab, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Lab Clin Biol, Dept Haematol, B-9000 Ghent, Belgium

[3] Katholieke Univ Leuven, Rega Inst, Med Chem Lab, B-3000 Louvain, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(99)00553-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3159 / 3164

页数：6

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