APC: the plot thickens

被引：86

作者：

Bienz, M ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(99)00016-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive.

引用

收藏

页码：595 / 603

页数：9

相关论文

共 72 条

[1]

beta-catenin is a target for the ubiquitin-proteasome pathway [J].

Aberle, H ;

Bauer, A ;

Stappert, J ;

Kispert, A ;

Kemler, R .

EMBO JOURNAL, 1997, 16 (13) :3797-3804

[2]

Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development [J].

Ahmed, Y ;

Hayashi, S ;

Levine, A ;

Wieschaus, E .

CELL, 1998, 93 (07) :1171-1182

[3]

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways [J].

Axelrod, JD ;

Miller, JR ;

Shulman, JM ;

Moon, RT ;

Perrimon, N .

GENES & DEVELOPMENT, 1998, 12 (16) :2610-2622

[4]

Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].

Behrens, J ;

Jerchow, BA ;

Würtele, M ;

Grimm, J ;

Asbrand, C ;

Wirtz, R ;

Kühl, M ;

Wedlich, D ;

Birchmeier, W .

SCIENCE, 1998, 280 (5363) :596-599

[5]

Functional interaction of beta-catenin with the transcription factor LEF-1 [J].

Behrens, J ;

vonKries, JP ;

Kuhl, M ;

Bruhn, L ;

Wedlich, D ;

Grosschedl, R ;

Birchmeier, W .

NATURE, 1996, 382 (6592) :638-642

[6]

pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila [J].

Brunner, E ;

Peter, O ;

Schweizer, L ;

Basler, K .

NATURE, 1997, 385 (6619) :829-833

[7]

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C [J].

Cook, D ;

Fry, MJ ;

Hughes, K ;

Sumathipala, R ;

Woodgett, JR ;

Dale, TC .

EMBO JOURNAL, 1996, 15 (17) :4526-4536

[8]

Cox RT, 1999, DEVELOPMENT, V126, P1327

[9]

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin [J].

Fagotto, F ;

Glück, U ;

Gumbiner, BM .

CURRENT BIOLOGY, 1998, 8 (04) :181-190

[10]

Domains of Axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization [J].

Fagotto, F ;

Jho, EH ;

Zeng, L ;

Kurth, T ;

Joos, T ;

Kaufmann, C ;

Costantini, F .

JOURNAL OF CELL BIOLOGY, 1999, 145 (04) :741-756

← 1 2 3 4 5 6 7 8 →