HIV-1 subtype A, D, G, AG and unclassified sequences identified in South Africa

被引：28

作者：

Bredell, H

Hunt, G

Casteling, A

Cilliers, T

Rademeyer, C

Coetzer, M

Miller, S

Johnson, D

Tiemessen, CT

Martin, DJ

Williamson, C

Morris, L

机构：

[1] Natl Inst Commuicable Dis, AIDS Virus Res Unit, ZA-2131 Johannesburg, South Africa

[2] Univ Cape Town, Div Med Virol, ZA-7925 Cape Town, South Africa

[3] Innovir Inst, ZA-2047 Johannesburg, South Africa

[4] Univ Witwatersrand, Dept Virol, ZA-2193 Johannesburg, South Africa

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2002年 / 18卷 / 09期

关键词：

D O I：

10.1089/088922202760019400

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-1 subtype C accounts for the vast majority of infections in South Africa. However, increasingly non-C subtypes are being detected. Here we report 10 viruses that contain sequences that group with subtypes A, D, and G as well as CRF02_AG and 1 that could not be classified. Most of these individuals were from other countries in Africa. Some of these sequences were in combination with subtype C, possibly indicating local recombination events. Although there is no indication of endemic spread of these viruses, continued monitoring is warranted to track genetic changes, which may impact on diagnostic testing, therapeutic responses to antiretroviral therapies, and vaccine design.

引用

页码：681 / 683

页数：3