Mycobacterium tuberculosis H37Rv:ΔRD1 is more virulent than M. bovis bacille Calmette-Guerin in long-term murine infection

被引：44

作者：

Sherman, DR

Guinn, KM

Hickey, MJ

Mathur, SK

Zakel, KL

Smith, S

机构：

[1] Univ Washington, Sch Publ Hlth & Community Med, Dept Pathobiol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2004年 / 190卷 / 01期

关键词：

D O I：

10.1086/421472

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Region of difference (RD1) genes are present in virulent Mycobacterium tuberculosis but not the vaccine strain M. bovis bacille Calmette-Guerin (BCG). The deletion of RD1 from M. tuberculosis produces an attenuation strikingly like that of BCG, which suggests the use of RD1 mutant strains for improvement of the tuberculosis (TB) vaccine. We performed long-term murine infection with M. tuberculosis H37Rv:DeltaRD1 and BCG. Mice infected with H37Rv:DeltaRD1 gained less weight than did BCG-infected control mice, and, after >1 year, their lungs harbored many more bacteria and displayed significant levels of inflammation. This difference in virulence has important implications for the pursuit of strains lacking RD1 in the development of the TB vaccine.

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页码：123 / 126

页数：4

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