Hierarchical Functional Modularity in the Resting-State Human Brain

被引：152

作者：

Ferrarini, Luca ^{[1
]}

Veer, Ilya M. ^{[2
,3
]}

Baerends, Evelinda ^{[2
,3
]}

van Tol, Marie-Jose ^{[2
,4
]}

Renken, Remco J. ^{[5
]}

van der Wee, Nic J. A. ^{[4
]}

Veltman, Dirk. J. ^{[6
]}

Aleman, Andre ^{[5
]}

Zitman, Frans G. ^{[4
]}

Penninx, Brenda W. J. H. ^{[4
,5
,6
]}

van Buchem, Mark A.

Reiber, Johan H. C. ^{[1
]}

Rombouts, Serge A. R. B. ^{[2
,3
]}

Milles, Julien ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Radiol, Div Image Proc,LKEB, NL-2333 ZA Leiden, Netherlands

[2] Leiden Univ, Med Ctr, LIBC, NL-2333 ZA Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Inst Psychol Res, NL-2333 ZA Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands

[5] Univ Groningen, BCN, NeuroImaging Ctr, Groningen, Netherlands

[6] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands

来源：

HUMAN BRAIN MAPPING | 2009年 / 30卷 / 07期

关键词：

resting state functional MRI; complex network; modularity; small world; COMMUNITY STRUCTURE; COMPLEX NETWORKS; FREQUENCY; ROBUST; CONNECTIVITY; OPTIMIZATION; REGISTRATION; EMERGENCE;

D O I：

10.1002/hbm.20663

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Functional magnetic resonance imaging (fMRI) studies have shown that anatomically distinct brain regions are functionally connected during the resting state. Basic topological properties in the brain functional connectivity (BFC) map have highlighted the BFC's small-world topology. Modularity, a more advanced topological property, has been hypothesized to be evolutionary advantageous, contributing to adaptive aspects of anatomical and functional brain connectivity. However, current definitions of modularity for complex networks focus on nonoverlapping clusters, and are seriously limited by disregarding inclusive relationships. Therefore, BFC's modularity has been mainly qualitatively investigated. Here, we introduce a new definition of modularity, based on a recently improved clustering measurement, which overcomes limitations of previous definitions, and apply it to the study of BFC in resting state fMRI of 53 healthy subjects. Results show hierarchical functional modularity in the brain. Hum Brain Mapp 30:2220-2231, 2009. (C) 2008 Wiley-Liss, Inc.

引用

页码：2220 / 2231

页数：12

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