IL-17 and Th17 cells in human inflammatory diseases

被引：322

作者：

Miossec, Pierre ^{[1
,2
]}

机构：

[1] Hop Edouard Herriot, Dept Immunol & Rheumatol, Lyon, France

[2] Univ Lyon, Immunogenom & Inflammat Res Unit EA 4130, Lyon, France

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 05期

关键词：

IL-17; Cytokines; Inflammation; Destruction; TNF alpha; IL-1; ACTIVE CROHNS-DISEASE; TUMOR-NECROSIS-FACTOR; HYPER-IGE SYNDROME; RHEUMATOID-ARTHRITIS; AUTOIMMUNE ENCEPHALOMYELITIS; T-CELLS; INTERLEUKIN (IL)-17; MONOCLONAL-ANTIBODY; COLLAGEN ARTHRITIS; BONE EROSION;

D O I：

10.1016/j.micinf.2009.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

IL-17 was discovered in 1995/96 as a T cell derived cytokine with effects on inflammation and neutrophil activation. In 2006, the precise cell source of IL-17 was identified in the mouse, and these cells were named Th17 cells. They play a role in various human diseases associated with inflammation and destruction such as rheumatoid arthritis, psoriasis, Crohn's disease, multiple sclerosis, where IL-17 can be seen as a therapeutic target. (C) 2009 Elsevier Masson SAS. All fights reserved.

引用

页码：625 / 630

页数：6

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