Linking Hebb's coincidence-detection to memory formation

被引:175
作者
Tsien, JZ [1 ]
机构
[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
关键词
D O I
10.1016/S0959-4388(00)00070-2
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain.
引用
收藏
页码:266 / 273
页数:8
相关论文
共 50 条
[1]
DISTINCT COMPONENTS OF SPATIAL-LEARNING REVEALED BY PRIOR TRAINING AND NMDA RECEPTOR BLOCKADE [J].
BANNERMAN, DM ;
GOOD, MA ;
BUTCHER, SP ;
RAMSAY, M ;
MORRIS, RGM .
NATURE, 1995, 378 (6553) :182-186
[2]
Bear Mark F., 1994, Current Opinion in Neurobiology, V4, P389, DOI 10.1016/0959-4388(94)90101-5
[3]
THEORY FOR THE DEVELOPMENT OF NEURON SELECTIVITY - ORIENTATION SPECIFICITY AND BINOCULAR INTERACTION IN VISUAL-CORTEX [J].
BIENENSTOCK, EL ;
COOPER, LN ;
MUNRO, PW .
JOURNAL OF NEUROSCIENCE, 1982, 2 (01) :32-48
[4]
A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[5]
ABNORMAL-BEHAVIOR ASSOCIATED WITH A POINT MUTATION IN THE STRUCTURAL GENE FOR MONOAMINE OXIDASE-A [J].
BRUNNER, HG ;
NELEN, M ;
BREAKEFIELD, XO ;
ROPERS, HH ;
VANOOST, BA .
SCIENCE, 1993, 262 (5133) :578-580
[6]
Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits [J].
Cain, DP ;
Saucier, D ;
Hall, J ;
Hargreaves, EL ;
Boon, F .
BEHAVIORAL NEUROSCIENCE, 1996, 110 (01) :86-102
[7]
Calabresi P, 1997, J NEUROSCI, V17, P4536
[8]
ACTIVITY-DEPENDENT DECREASE IN NMDA RECEPTOR RESPONSES DURING DEVELOPMENT OF THE VISUAL-CORTEX [J].
CARMIGNOTO, G ;
VICINI, S .
SCIENCE, 1992, 258 (5084) :1007-1011
[9]
Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests [J].
Crawley, JN .
BRAIN RESEARCH, 1999, 835 (01) :18-26
[10]
Molecular mechanisms of synaptic plasticity and memory [J].
Elgersma, Y ;
Silva, AJ .
CURRENT OPINION IN NEUROBIOLOGY, 1999, 9 (02) :209-213