Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness

被引：65

作者：

Chautard, Emmanuel ^{[1
,2
]}

Ouedraogo, Zangbewende Guy ^{[1
,2
,3
]}

Biau, Julian ^{[1
,2
,4
]}

Verrelle, Pierre ^{[1
,2
]}

机构：

[1] Clermont Univ, Univ Auvergne, CREaT EA7283, F-63000 Clermont Ferrand, France

[2] Ctr Jean Perrin, Lab Radiooncol Expt, F-63011 Clermont Ferrand, France

[3] Univ Ouagadougou, Lab Pharmacol Toxicol & Chim Therapeut, Ouagadougou, Burkina Faso

[4] INSERM U2021, CNRS UMR3347, Inst Curie, F-91405 Orsay, France

来源：

JOURNAL OF NEURO-ONCOLOGY | 2014年 / 117卷 / 02期

关键词：

Akt; Human malignant glioma; Resistance to treatment; PROTEIN-KINASE B; NF-KAPPA-B; GLIOBLASTOMA-MULTIFORME; SIGNALING PATHWAY; MOLECULAR-CLONING; EVEROLIMUS RAD001; RADIATION-THERAPY; PHASE-II; PHOSPHATIDYLINOSITOL; 3-KINASE; ABERRANT EXPRESSION;

D O I：

10.1007/s11060-014-1382-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Gathering evidence has revealed that Akt signaling pathway plays an important role in glioma progression and aggressiveness. Among Akt kinases the most studied, Akt1, has been involved in many cellular processes that are in favor of cell malignancy. More recently, the actions of the two other isoforms, Akt2 and Akt3 have emerged in glioma. After a description of Akt pathway activation, we will explore the role of each isoform in malignant glioma that strengthens the current preclinical and clinical studies evaluating the impact of Akt pathway targeting in glioblastomas.

引用

收藏

页码：205 / 215

页数：11

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