Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c

被引：100

作者：

Stehling-Sun, Sandra ^{[1
]}

Dade, Jessica ^{[2
]}

Nutt, Stephen L. ^{[3
]}

DeKoter, Rodney P. ^{[2
]}

Camargo, Fernando D. ^{[1
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA

[3] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 03期

基金：

美国国家卫生研究院;

关键词：

B-CELL DEVELOPMENT; HEMATOPOIETIC PROGENITORS; SELF-RENEWAL; BONE-MARROW; C/EBP-ALPHA; STEM-CELLS; PU.1; EXPRESSION; ENHANCER; GENE;

D O I：

10.1038/ni.1694

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite advances in the identification of lymphoid-restricted progenitor cells, the transcription factors essential for their generation remain to be identified. Here we describe an unexpected function for the myeloid oncogene product Mef2c in lymphoid development. Mef2c deficiency was associated with profound defects in the production of B cells, T cells, natural killer cells and common lymphoid progenitor cells and an enhanced myeloid output. In multipotent progenitors, Mef2c was required for the proper expression of several key lymphoid regulators and restriction of the myeloid fate. Our studies also show that Mef2c was a critical transcriptional target of the transcription factor PU.1 during lymphopoiesis. Thus, Mef2c is a crucial component of the transcriptional network that regulates cell fate 'choice' in multipotent progenitors.

引用

页码：289 / 296

页数：8

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