Homeobox genes and disease

被引：76

作者：

Boncinelli, E ^{[1
]}

机构：

[1] CNR,INST CELLULAR & MOL PHARMACOL,MILAN,ITALY

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(97)80146-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To date, not many disorders have been associated with homeobox genes, especially with those belonging to the HOX family. This is particularly surprising, considering the body of evidence accumulated for a role of these genes in the control of mammalian development. Recently, this situation has changed and some congenital or somatic defects have been demonstrated to involve mutations in homeobox genes of the HOX, EMX, PAX, and MSX families, as well as in other novel genes containing either a paired- or bicoid-type homeobox.

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页码：331 / 337

页数：7

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