Inflammasome and Atherogenesis

被引:40
作者
Lu, Xinjie [1 ]
Kakkar, Vijay [1 ]
机构
[1] Thrombosis Res Inst, Mary & Garry Weston Mol Immunol Lab, London SW3 6LR, England
关键词
Inflammasome; atherosclerosis; atherosgenesis; autophagy; caspase; LOW-DENSITY-LIPOPROTEIN; LINKS OXIDATIVE STRESS; TOLL-LIKE RECEPTORS; KAPPA-B ACTIVATION; NOD-LIKE RECEPTORS; DEATH DOMAIN FADD; NLRP3; INFLAMMASOME; NALP3; NEOINTIMAL FORMATION; INNATE IMMUNITY;
D O I
10.2174/13816128113199990586
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. Inflammation and the innate immune response are involved in the formation of early atherosclerotic lesion. A protein complex known as the inflammasome is stimulated to activate interleukin-1 beta (IL-1 beta) and IL-18, which are responsible for activation of inflammatory processes. Inflammasome-mediated processes are important in the process of atherosclerosis. The front of structure domains as well as IL-1, and IL-18 stands at the threshold of the adaptive immune response that accelerates full-blown atherosclerotic disease progression. This review is intended to provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for therapy of this disease.
引用
收藏
页码:108 / 124
页数:17
相关论文
共 177 条
[1]
Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation [J].
Acehan, D ;
Jiang, XJ ;
Morgan, DG ;
Heuser, JE ;
Wang, XD ;
Akey, CW .
MOLECULAR CELL, 2002, 9 (02) :423-432
[2]
Elevated levels of interleukin-1β-converting enzyme and caspase-cleaved cytokeratin-18 in acute myocardial infarction [J].
Adlbrecht, C. ;
Hoetzenecker, K. ;
Posch, M. ;
Steiner, S. ;
Kopp, C. ;
Hacker, S. ;
Auer, J. ;
Horvath, R. ;
Moser, B. ;
Roth, G. ;
Wolner, E. ;
Lang, I. M. ;
Ankersmit, H. J. .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2007, 37 (05) :372-380
[3]
Agis-Balboa RC, 2011, EMBO J, V30, P4701
[4]
DEDD and DEDD2 associate with caspase-8/10 and signal cell death [J].
Alcivar, A ;
Hu, SM ;
Tang, J ;
Yang, XL .
ONCOGENE, 2003, 22 (02) :291-297
[5]
Patterns and risk factors for systemic calcified atherosclerosis [J].
Allison, MA ;
Criqui, MH ;
Wright, CM .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (02) :331-336
[6]
[Anonymous], 2012, NATURE, V490, P539
[7]
Apoptosis control by death and decoy receptors [J].
Ashkenazi, A ;
Dixit, VM .
CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) :255-260
[8]
Interleukin-18: a potent pro-inflammatory cytokine in atherosclerosis [J].
Badimon, Lina .
CARDIOVASCULAR RESEARCH, 2012, 96 (02) :172-175
[9]
Everolimus Inhibits Monocyte/Macrophage Migration in Vitro and Their Accumulation in Carotid Lesions of Cholesterol-Fed Rabbits [J].
Baetta, Roberta ;
Granata, Agnese ;
Canavesi, Monica ;
Ferri, Nicola ;
Arnaboldi, Lorenzo ;
Bellosta, Stefano ;
Pfister, Pascal ;
Corsini, Alberto .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 328 (02) :419-425
[10]
Microarray-based gene expression profiling in patients with cryopyrin-associated periodic syndromes defines a disease-related signature and IL-1-responsive transcripts [J].
Balow, James E., Jr. ;
Ryan, John G. ;
Chae, Jae Jin ;
Booty, Matthew G. ;
Bulua, Ariel ;
Stone, Deborah ;
Sun, Hong-Wei ;
Greene, James ;
Barham, Beverly ;
Goldbach-Mansky, Raphaela ;
Kastner, Daniel L. ;
Aksentijevich, Ivona .
ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (06) :1064-1070