Study of the green polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors

被引：67

作者：

Wan, SB

Chen, D

Dou, QP

Chan, TH ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[3] Wayne State Univ, Sch Med, Prevent Program, Barbara Ann Karmanos Canc Inst, Detroit, MI USA

[4] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 13期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.bmc.2004.04.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The green tea polyphenol catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) were synthesized enantioselectively via a Sharpless hydroxylation reaction followed by a diastereoselective cyclization. Their potencies to inhibit the proteasome activity were measured. The unnatural enantiomers were found to be equally potent to the natural compounds. (C) 2004 Elsevier Ltd, All rights reserved.

引用

页码：3521 / 3527

页数：7

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