Lysophosphatidic acid: G-protein signalling and cellular responses

被引：468

作者：

Moolenaar, WH

Kranenburg, O

Postma, FR

Zondag, GCM

机构：

[1] Division of Cellular Biochemistry, Netherlands Cancer Institute, 1066 X Amsterdam

来源：

CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(97)80059-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates a specific G protein coupled receptor to evoke multiple cellular responses. Recent work has identified two cDNAs encoding putative LPA receptors, Various LPA-like agonists that act on distinct receptors, and new pathways that link the receptor(s) to such diverse events as Ras signalling, cytoskeletal remodelling and membrane depolarization.

引用

页码：168 / 173

页数：6

共 48 条

[1] G-ALPHA(12) AND G-ALPHA(13) STIMULATE RHO-DEPENDENT STRESS FIBER FORMATION AND FOCAL ADHESION ASSEMBLY
BUHL, AM
JOHNSON, NL
DHANASEKARAN, N
JOHNSON, GL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (42) : 24631 - 24634
[2] A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes
Bunemann, M
Liliom, K
Brandts, BK
Pott, L
Tseng, JL
Desiderio, DM
Sun, GP
Miller, D
Tigyi, G
[J]. EMBO JOURNAL, 1996, 15 (20) : 5527 - 5534
[3] CZRANOWSKAWODNI.M, 1996, J CELL BIOL, V133, P1403
[4] Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
Daub, H
Weiss, FU
Wallasch, C
Ullrich, A
[J]. NATURE, 1996, 379 (6565) : 557 - 560
[5] A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
Dikic, I
Tokiwa, G
Lev, S
Courtneidge, SA
Schlessinger, J
[J]. NATURE, 1996, 383 (6600) : 547 - 550
[6] SECRETORY PHOSPHOLIPASE A(2) GENERATES THE NOVEL LIPID MEDIATOR LYSOPHOSPHATIDIC ACID IN MEMBRANE MICROVESICLES SHED FROM ACTIVATED CELLS
FOURCADE, O
SIMON, MF
VIODE, C
RUGANI, N
LEBALLE, F
RAGAB, A
FOURNIE, B
SARDA, L
CHAP, H
[J]. CELL, 1995, 80 (06) : 919 - 927
[7] Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes
Guo, Z
Liliom, K
Fischer, DJ
Bathurst, IC
Tomei, LD
Kiefer, MC
Tigyi, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14367 - 14372
[8] Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway
Hawes, BE
Luttrell, LM
vanBiesen, T
Lefkowitz, RJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) : 12133 - 12136
[9] Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
Hecht, JH
Weiner, JA
Post, SR
Chun, J
[J]. JOURNAL OF CELL BIOLOGY, 1996, 135 (04) : 1071 - 1083
[10] LYSOPHOSPHATIDIC ACID INHIBITS GAP-JUNCTIONAL COMMUNICATION AND STIMULATES PHOSPHORYLATION OF CONNEXIN-43 IN WB CELLS - POSSIBLE INVOLVEMENT OF THE MITOGEN-ACTIVATED PROTEIN-KINASE CASCADE
HII, CST
OH, SY
SCHMIDT, SA
CLARK, KJ
MURRAY, AW
[J]. BIOCHEMICAL JOURNAL, 1994, 303 : 475 - 479

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