What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

被引：61

作者：

Bastos, KRB ^{[1
]}

Marinho, CRF ^{[1
]}

Barboza, R ^{[1
]}

Russo, M ^{[1
]}

Alvarez, JM ^{[1
]}

Lima, MRD ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Imunol, BR-05508900 Sao Paulo, Brazil

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 06期

关键词：

IL-12; IL-23; macrophage; dendritic cell; TGF-beta; 1; IFN-gamma; nitric oxide;

D O I：

10.1016/j.micinf.2004.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element between accessory cells and lymphocytes, but it is also a key molecule for programming the macrophage and dendritic cell functions. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：630 / 636

页数：7

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